When Roger's life flashed before his eyes, we see that he attended a protest rally against the racial integration of the University of Alabama which originally occurred in 1963, was partially responsible for the "EL Valdez", a riff on the Exxon Valdez oil spill in 1989 and created Jar-Jar Binks for George Lucas.
Cristofani's "Shake it Up" plays in the bar with Roger.
The song that plays as Roger sees what Stan does with Andy Dick is "Honey Dove" by Lee Fields and the Expressions.
The theme of Magnum, P.I. plays when Roger finds his fanny pack and later during the chase.
When Roger is taking Stan to get his special salve in Area 51, they pass by a stasis tank holding Gertie, the racist old lady Stan claims is an alien to save Roger in "Roger Codger". However, in "100 A.D.", she was on the doomed bus.
As Hayley states in this episode that the life debt is repaid, but in "Office Spaceman", Stan saves Roger from being dissected. Thus saving his life and repaying the life debt.