Vatican City, or Vatican City State is a landlocked sovereign city-state whose territory consists of a walled enclave within the city of Rome, Italy. Vatican City is an ecclesiastical or sacerdotal-monarchical state, ruled by the Bishop of Rome —the Pope. The highest state functionaries are all Catholic clergymen of various national origins. It is the sovereign territory of the Holy See (Sancta Sedes) and the location of the Pope's residence, referred to as the Apostolic Palace.
In 'Season's Beatings", Stan Smith, Roger and Jeff Fischer travel to the Vatican to obtain a set of sacred daggers to kill Nemo whom Stan believes is the Anti-Christ. Although Stan is barred from entering, Roger and Jeff are able to enter the catacombs to search. Nemo sees them through the eyes of a rat and causes the catacombs to flood, washing Jeff away. Roger climbs out and finds the daggers and escapes with them after attacking a Cardinal.