After almost 4 years, Dan Vebber returns to the show as co-executive producer starting this episode.
Klaus makes no appearance in this episode.
"Thank Heaven for Little Girls", performed by Maurice Chevalier from the film Gigi plays over the montage of the girls growing up.
The girls come down the stairs to "Get Ur Freak on" by Missy Elliot. It changes to "My Girl" by the Temptations.
George Clooney appears on the cover of a People magazine Stan reads while sitting with Honey.
Stan says that Honey's birthday, the 30th, is the same as Selena Gomez's. Selena Gomez's birthday is actually July 22nd.
Stan says that the dodo went extinct in 1662, and Francine mentioned that it was the same year French poet François le Métel de Boisrobert died.
Stan says George Burns played God, and that he was now dead. This is referring to the 1977 film Oh, God!.
A setting on the cloning machine is "Fly-Goldblum Hybrid", a homage to the 1986 film The Fly. A cloning attempt results in a Glitter-Daren hybrid.
Vince Chung asked Steve if he's ever touched a woman's breasts, and Steve replies that he was breastfed. He did touch Lindsay Coolidge's breast in "Big Trouble in Little Langley", but did not have the ability to actually feel them.
Steve and Snot ask Hayley for advice on getting hot prom dates despite Snot lying to Hayley about being gay in "The Missing Kink".