- The title is a play on the phrase "Man's best friend".
- Stan says he's going Lorenzo's oil in seeking his own cure for Kisses, referring to the film of the same name about the true story of two parents search for a cure for their son Lorenzo's adrenoleukodystrophy (ALD).
- Roger trying to trick Stan with popcorn on his crotch imitates a scene from the film Diner.[1]
Previous Episode's References /// Stan's Best Friend's References \\\ Next Episode's References
| << Season 6 | American Dad Season 7 | Season 8 >> | |||||||||
| #01 | Hot Water | #07 | Season's Beatings | #13 | Dr. Klaustus | ||||||
| #02 | Hurricane! | #08 | The Unbrave One | #14 | Stan's Best Friend | ||||||
| #03 | A Ward Show | #09 | Stanny Tendergrass | #15 | Less Money, Mo' Problems | ||||||
| #04 | The Worst Stan | #10 | Wheels & the Legman and the Case of Grandpa's Key | #16 | The Kidney Stays in the Picture | ||||||
| #05 | Virtual In-Stanity | #11 | Old Stan in the Mountain | #17 | Ricky Spanish | ||||||
| #06 | The Scarlett Getter | #12 | The Wrestler | #18 | Toy Whorey | ||||||