- The episode's title is a reference to spring break.
- At the beginning of the party, a pirate skeleton from Disneyland's "Pirates of the Caribbean" ride is in the living room.
- While talking to Stan and Jessica about the Tunnel of Booze, Roger says "In the time of chimpanzees I was a monkey...", the opening lyrics to Beck's song "Loser".
- Before Francine comes home, we see a short few seconds of an ape on top of a pyramid of kegs throwing kegs down at laughing frat boys. This a reference to the original 1981 arcade game Donkey Kong.
Previous Episode's References /// Spring Break-Up's References \\\ Next Episode's References
| << Season 2 | American Dad Season 3 | Season 4 >> | ||||||
| #01 | The Vacation Goo | #07 | Surro-Gate | #13 | Red October Sky | |||
| #02 | Meter Made | #08 | The Most Adequate Christmas Ever | #14 | Office Spaceman | |||
| #03 | Dope & Faith | #09 | Frannie 911 | #15 | Stanny Slickers 2: The Legend of Ollie's Gold | |||
| #04 | Big Trouble in Little Langley | #10 | Tearjerker | #16 | Spring Break-Up | |||
| #05 | Haylias | #11 | Oedipal Panties | |||||
| #06 | 42-Year-Old Virgin | #12 | Widowmaker | |||||
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