The Harlem Globetrotters are an exhibition basketball team that over the years have played more than 26,000 exhibition games in 122 countries and territories. The team's signature song is Brother Bones' whistled version of "Sweet Georgia Brown".
Stan blows a bust of an arms dealer when he suffers an anxiety attack over being yelled at n "Klaustastrophe.TV". After seeing the CIA psychologist, Dr. Ray Petit, he discovers he has issues stemming from when he believes he was kicked out of the Harlem Globetrotters basketball camp by Curly Neal. Taking in a game, he finds out that the newest generation of players are unfamiliar with the old squad, but he is redirected to a farm where they spend their retirement. He finds out that he wasn't really kicked out of a camp, but that the players tried to take him in when he was abandoned by his father and they had to return him when he came back.
Energized, Stan decides to work as a 'lone wolf' to go after the dealer but finds himself captured. Thanks to a tracking chip implanted by the doctor, he leads the Globetrotters to Stan and they attempt a rescue, but are surrounded and facing death as well. As they hear gunfire, they are surprised to be alive as Avery Bullock had led a CIA team to a chip in Stan as well.
The introduction to Morning Mimosa's Liquid Lunch in "Gold Top Nuts" shows a stew being made with a Harlem Globetrotter.
Three Harlem Globetrotters are members of the Z.O.I.N.C.S. team in "Z.O.I.N.C.S.".