Guffrie is Santa Claus' lead elf in "Into the Jingleverse", who becomes exasperated when his boss delays making his ride in order to talk with Stan.
When Stan travels to the North Pole with Roger in order to ask Santa for a virtual reality headset for Steve for Christmas, he finds the family's erstwhile enemy in a pleasant mood and the pair find they have much in common. Santa shows off his own "JollyGoggles" virtual reality headset that makes it Christmas year round, and they agree to use the Smith family as beta testers.
The family awakens to find themselves in a crude virtual world. When they try to remove the goggles, they find they are fused to their face as Santa reveals be springing the goggles on the entire world the following year. However, Stan realizes that, since everyone can smell his eggnog gas from being lactose intolerant in real life, they all, including Santa, must be in the same room. Despite his vision being obscured by the goggles, Stan manages to wander around the room and eventually gets into a slap fight with Santa. With his elves unwilling to help, Santa proposes a deal where Stan joins him and leaves the family in the Jingleverse, but he refuses. They both make another appeal to the elves, and Stan's suggestion that they take over for Santa wins them over, freeing the family as Guffrie declares himself the new Santa.