George Timothy Clooney (born May 6, 1961) is an American actor, film director, producer, screenwriter, voice artist, and comedian.

Francine had selected Clooney as her one free kill in "Deacon Stan, Jesus Man", calling him a "smug bastard."

George Clooney had a prominent role in "Tears of a Clooney". Francine and Stan decide to emotionally destroy him as revenge for him interrupting Francine's extra scene on a TV show, by having Francine seduce him only to then break up with him. Stan becomes best friends with Clooney foiling the plan. Stan then "breaks up" with Clooney to get Francine off his back, much to his disappointment.

George Clooney appears as one of the celebrity robots in "Tearjerker".

George appears on the cover of a People magazine Stan reads while sitting with Honey in "Steve and Snot's Test-Tubular Adventure".

George is voiced by Andre Sogliuzzo.