Frog Rose is the sister of Frog Ross, eventually taking over his chain of restaurants.
In "The Pink Sphinx Holds Her Hearts on the Turn", she also own the Chimdale Stakes Casino where Roger takes Francine to advance her poker skills in an effort to hide her thoughts from her kids. When pressed on her new lifestyle, Francine becomes determined to win at a very high stakes poker match and get Rose to sponsor her. To convince her to give up, the kids also enter the tournament, with Steve eventually beating Francine.
For losing, Francine finds herself forced to work for eternity in Frog Rose Illegal Gamblery. Roger and the kids attempt to rescue her by putting themselves up as stakes in a game between Francine and Rose. Francine, who had been in a deep catatonic state, reveals that she had been hiding her thoughts and manages to bluff her way to victory against Rose.
Rose is voiced by Debra Wilson