Roger's persona of Stan's brother "Applebee McFridays" is a pun on the restaurant chains Applebees, McDonalds and Fridays, also known as TGI Fridays.
Chairman Meow gets his name from Mao Tse-tung, colloquially known as Chairman Mao, ruler of Communist China from 1949 until his death in 1976.
Fatso, the "keyboard cat" appears as the "lost tribe" watch videos on cell phones.
Mercyville was established in 1883.
When Stan is talking to Hayley at the party, Stan tells her that her grandmother had drowned in her swim suit. All three of her grandmothers, Stan's mother Betty Smith, Francine's birth mother Cassandra Dawson and Francine's adoptive Ma Ma Ling are all still alive.
The red bikini Hayley wears is the same one she would later wear in "Son of Stan".
Snoopy (as Red Baron) is one of the people that gave Stan bad advice in his extended fantasy sequences prior to Barack Obama but Snoopy fought against the Red Baron, not acting as him. Other people that gave Stan bad advice in his extended fantasy sequences prior to Barack Obama include:
Dirk Diggler from Boogie Nights
In the uncensored DVD version, Roger (as Winfrey) does indeed say "dildos", which was censored in the original version.