- This episode is celebrated as American Dad!'s 100th episode by production order. "Stan's Food Restaurant" was the 100th episode to be broadcast.
- The episode marked its 100th episode by killing off 100 characters. The seen characters included in the count:
- A dog killed in a gas station bathroom.
- Mr. Kirkoff
- Ted Feedler
- Black-haired stripper from "G-String Circus"
- Bjorn
- Tanqueray
- Paco
- Belmonpan
- Katie
- Chipmunk Furry from "One Little Word"
- Meg Penner
- Mr. Aids
- Meter attendant beaten up by Stan in "Meter Made"
- Beauregard LaFontaine
- Montague
- Clifford
- Bob Hope impersonator from "In Country...Club"
- Woman with white blonde hair
- Tall-headed man
- Balding man with glasses seen at the Smith's party in "Homeland Insecurity"
- Overweight woman seen at the Smith's party in "Homeland Insecurity"
- Alejandro Roja
- Pillow Hands McGraw
- Bus Driver from "Of Ice and Men"
- Ray
- Matty Moyer
- Gertie
- Street racer from "Dungeons and Wagons"
- Man with glasses and no tie
- Casey
- Coco
- Arboreus
- Arboreus gang member
- Clown with Glasses
- Duper
- Brett Morris
- Bobby the Bullet
- Hotel manager
- The death count was as follows:
- A dog exploded when Stan Smith looked for Hayley Smith's chip (Death 1).
- A bus fell off a cliff (Deaths 2-97).
- Brent Morris was impaled by Bobby The Bullet (Deaths 98-99).
- The hotel manager hung himself by a noose (Death 100).
(Whilst the majority of these characters never appear again, some have appeared in non-speaking or brief-speaking roles afterwards)
- The Wilhelm Scream is heard when the bus falls off the cliff.
- Reginald Koala's limo's license plate reads 307 HSV (Holden Special Vehicle), an Australian super car. 307 is a reference to the engine power in kw.
- While allowing for the various season counts, Brett Morris actually appeared in the third episode of the season, not second as he says.
- The bus crash is said to have killed 96 people, but not even 50 people appear to be on the bus. However, it did crash onto a busy freeway below the cliff and exploded, presumably killing other motorists.
- Snot, Barry and Toshi are riding their bikes on one lane of the road, but the cars on the other lane are traveling the same way.
- Roger mentions the Simpsons two-part episode, "Who Shot Mr. Burns?" where at the end it was revealed it was Maggie.
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